The patch clamp has been widely accepted as a standard technique for fundamental studies of ion channel proteins, and discovery of drugs that affect these proteins. Traditional patch clamp has a very low throughput which has been proven to be a bottleneck for the drug discovery process. Planar patch-clamp electrode array, which is scaleable and …
Tag Archive: General
Mar
12
Optimization and characterization of multifunctional polymeric-nanodiamond electrospun scaffolds
Due to the lack of treatment options available for patients suffering from bone abnormalities, current research focuses on developing novel biomaterials for bone tissue engineering. Since a tissue scaffold is implanted in vivo, it could also serve as a substrate for localized, systemic delivery of therapeutics. Particularly in primary bone cancer after removal of a …
Mar
11
Learning to Predict Protein Location and Network Properties via Knowledge Transfer
Many new results are being obtained in bioinformatics through the application of machine learning and data mining, which allow the discovery of useful knowledge from biological datasets and reveal the underlying mechanisms in various genomics and proteomics problems. High-quality machine learning models critically depend on the availability of data, especially for supervised learning techniques. However, …
Mar
09
Experimental investigation of a non-thermal atmospheric pressure plasma jet
The main objective of this dissertation is to understand the formation of the plasma jet from the plasma pencil, and the propagation of the plasma jet in the ambient atmosphere where the effect of the external electric field is almost zero. Before investigating the formation and propagation phenomenon of the plasma jet, common physical properties …
Mar
08
Multi-layered microfluidic devices for cellular functional studies
Currently, we are heading towards the period of nanotechnology which extends to many engineering disciplines. The necessity of its development is crucial to make life more convenient, to improve efficiency of each research field, and to integrate portable point-of-care system. Thus, the next most important step is to develop a technology to meet the needs …
Mar
06
Band structure calculations of strained semiconductors using empirical pseudopotential theory
Electronic band structure of various crystal orientations of relaxed and strained bulk, 1D and 2D confined semiconductors are investigated using nonlocal empirical pseudopotential method with spin-orbit interaction. For the bulk semiconductors, local and nonlocal pseudopotential parameters are obtained by fitting transport-relevant quantities, such as band gap, effective masses and deformation potentials, to available experimental data. …
Mar
02
Preference based fair allocation of limited resources
The fair division of scarce resources among agents is a challenging issue across a range of applications, especially when there is competition among agents. One application of resource division is in Air Traffic Management ATM). During severe weather, when there is a reduction in en-route capacity, a specialist using the TSD Traffic Situation Display) identifies …
Mar
02
Nonnative aggregation of alpha-chymotrypsinogen A and related systems
Nonnative protein aggregation is a type of protein self-assembly in which the resulting soluble or insoluble aggregates are composed of monomers with secondary structures that are significantly different from the native monomer) state. The presence of even small amounts of nonnative aggregates in protein-based therapeutics may elicit a potentially dangerous immune response or otherwise negatively …
Feb
24
Modeling and evaluating security screening with other inspection models
Since the 9/11/2001 terrorist attacks on U.S. soil, research related to national security within the nation’s airports has advanced. Numerous studies focus on the capabilities and limitations of the airport’s security screener’s, which essentially perform an inspection process. There is a strong history of inspection literature, in manufacturing or non-destructive inspection, found within both Industrial …
Feb
24
Artificial Underwater Electrolocation
Electric Fields can be used as a means of underwater detection, localization and characterization of objects. Observations of certain species of weakly electric fish suggest the possibility of near-field underwater detection capabilities through the use of biologically inspired electrolocation. A system featuring a dipolar electric field source, analogous to the electric discharge organ of weakly …