The patch clamp has been widely accepted as a standard technique for fundamental studies of ion channel proteins, and discovery of drugs that affect these proteins. Traditional patch clamp has a very low throughput which has been proven to be a bottleneck for the drug discovery process. Planar patch-clamp electrode array, which is scaleable and …
Tag Archive: Biophysics
Mar
12
Multiparameter data analysis and visualization for a multianalytical clinical chemistry-diabetes chip
Miniaturization of clinical chemistry analyzers will help transform clinical chemical testing from central laboratories to direct point-of-care using clinical chemistry chips which measure a small array of analytes, are small, portable, fast, easy-to-operate, and inexpensive. This dissertation is focused on developing an information processing unit “InfoWare” for a clinical chemistry chip, in general, and a …
Mar
12
Evaluating the effect of pattern of inflation and deflation and cycle time on the pressure relieving characteristic of a dynamic seat cushion using seat interface pressure measurements
Ulceration due to pressure can occur in any individual who is restricted to a prolonged stay in a bed or a chair with no pressure relief. Intermittent pressure relief has been recommended as a means to lower the risk of pressure ulcer development. Active cushions cyclically change the area of exposure to pressure. The design …
Mar
11
Learning to Predict Protein Location and Network Properties via Knowledge Transfer
Many new results are being obtained in bioinformatics through the application of machine learning and data mining, which allow the discovery of useful knowledge from biological datasets and reveal the underlying mechanisms in various genomics and proteomics problems. High-quality machine learning models critically depend on the availability of data, especially for supervised learning techniques. However, …
Mar
10
Influence of hydrodynamic stresses, cellular mechanics and environmental conditions on epithelial cell injury during airway reopening
Acute Respiratory Distress Syndrome (ARDS) is a common and devastating lung disorder. In spite of the tremendous amount of research on this subject, many of the mechanisms responsible for the initiation and progression of this disease are not understood. Although the mechanical forces generated by ventilating patients with large volumes have been investigated, the consequences …
Mar
10
Bone marrow edema and bone morphometric changes as diagnostic surrogates of early osteoarthritis
Osteoarthritis (OA) is a chronic degenerative joint disease, characterized by the full thickness loss of cartilage, which is usually diagnosed by radiological assessment processes. The goal of this study was to develop diagnostic surrogates of OA utilizing magnetic resonance imaging and computed tomography. Our study focused on bone marrow lesions and morphometric bony changes in …
Mar
09
Contrast-generation techniques for rapid magnetic resonance imaging
Magnetic resonance imaging MRI) is a potent medical imaging modality that effectively depicts the morphology and function of biological tissues. Due to its excellent soft-tissue contrast, MRI is particularly useful in the diagnosis and therapeutic assessment of many diseases, and has found wide clinical use in areas such as neurological or cardiovascular imaging. Furthermore, a …
Mar
09
Experimental investigation of a non-thermal atmospheric pressure plasma jet
The main objective of this dissertation is to understand the formation of the plasma jet from the plasma pencil, and the propagation of the plasma jet in the ambient atmosphere where the effect of the external electric field is almost zero. Before investigating the formation and propagation phenomenon of the plasma jet, common physical properties …
Mar
09
Mechanical and structural characterization of ascending aortic tissues and graft materials used in the aortic arch reconstruction
The exact mechanisms involved in the pathogenesis of aortic aneurysms of the human ascending aorta (AA) are unknown. It is believed that the remodeling capabilities of the endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) combined with abnormal and non-uniform shear and tissue stresses, generated by a perturbed hemodynamics produced by a diseased aortic …
Mar
08
Techniques for extended modeling of cardiac morphogenesis in the embryonic chick
Computational models that simulate the biophysical mechanisms of early cardiac morphogenesis in the embryonic chick heart have been used to demonstrate the influence of biomechanics in cardiac development. However, algorithms for the automatic coding of material subroutines that govern the constitutive relations of biological tissues, generating realistic: geometries, transferring solution results correctly during analysis continuation …